Hyperhomocysteinemia

Hyperhomocysteinemia is elevated blood homocysteine, an amino acid byproduct. It is associated with increased risk of clots, cardiovascular disease, and pregnancy complications.

Table of Contents

Causes

  • Folate, B12, or B6 deficiency
  • MTHFR gene variants
  • Kidney disease
  • Hypothyroidism
  • Medications (methotrexate, anticonvulsants)

Treatment

  • Vitamin replacement (folate, B12, B6)
  • Lower homocysteine, but evidence that this reduces cardiovascular events is mixed

Related Conditions

Homocystinuria

Inherited form

 Vitamin Deficiency

Cause
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.

References

  • AHA. Homocysteine Resources.