Factor V Leiden
Factor V Leiden is a genetic mutation that makes blood more likely to clot. It is the most common inherited thrombophilia. Most people with one copy never develop clots, but the risk is increased.
Table of Contents
Quick Facts
- ICD-10: D68.51
- Inheritance: Autosomal codominant
What It Means
- Heterozygous (one copy) — modestly increased risk of DVT/PE
- Homozygous (two copies) — substantially increased risk
- Risk multiplies with other factors (hormones, surgery, immobility, pregnancy)
Management
- No treatment if no history of clots
- Avoid combined hormonal contraceptives if possible
- DVT prophylaxis with surgery, immobility, pregnancy
- Anticoagulation after a clot (duration based on circumstances)
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.
References
- American Society of Hematology. Thrombophilia Resources.