Platelet Function Disorders

Platelet function disorders cause bleeding because platelets don't work properly, even if their numbers are normal. Causes can be inherited (von Willebrand disease, Glanzmann's) or acquired (medications, kidney disease).

Table of Contents

Causes

  • Von Willebrand disease (most common inherited bleeding disorder)
  • Glanzmann thrombasthenia, Bernard-Soulier (rare inherited)
  • Aspirin and NSAIDs
  • Kidney disease (uremia)
  • Some blood cancers

Treatment

  • Desmopressin (DDAVP) for von Willebrand and others
  • Antifibrinolytics (tranexamic acid)
  • Platelet transfusion for severe bleeding or before procedures
  • Stop offending medications
  • Treat underlying cause (e.g., dialysis improves uremic platelet dysfunction)

Related Conditions

Coagulation Disorder

Broader category

 Easy Bruising

Common feature
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.

References

  • ASH. Bleeding Disorders Resources.