Multiple System Atrophy (MSA)
Multiple system atrophy (MSA) is a rare, progressive neurodegenerative disorder that affects movement, blood pressure, balance, bladder function, and other autonomic processes. It can resemble Parkinson's disease but progresses faster and responds less well to standard Parkinson's medications.
Quick Facts
- ICD-10: G90.3
- Type: Progressive neurodegenerative
Symptoms
- Parkinsonism — slow movement, stiffness, balance problems
- Cerebellar features — uncoordinated movements, slurred speech
- Orthostatic hypotension (lightheadedness on standing)
- Urinary problems
- Erectile dysfunction (often an early feature in men)
- Constipation
- REM sleep behavior disorder
- Soft, hoarse voice
Diagnosis
Diagnosis is clinical. MRI may show characteristic changes. There is no definitive test during life; brain examination at autopsy confirms diagnosis.
Treatment
- Levodopa (may help some but less than in Parkinson's)
- Treatments for orthostatic hypotension (midodrine, fludrocortisone, support stockings)
- Bladder management
- Physical, occupational, and speech therapy
- Treatment of constipation, sleep, and other symptoms
- Multidisciplinary supportive care
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.
References
- MSA Coalition. Patient and Family Resources.