Mixed Connective Tissue Disease (MCTD)
Mixed connective tissue disease (MCTD) is an autoimmune disorder that combines features of lupus, scleroderma, polymyositis, and rheumatoid arthritis. A specific antibody (anti-U1 RNP) helps confirm the diagnosis.
Table of Contents
Quick Facts
- ICD-10: M35.1
- Hallmark antibody: Anti-U1 RNP
Common Features
- Raynaud's phenomenon
- Swollen, puffy hands and fingers
- Joint pain and arthritis
- Muscle pain and weakness
- Fatigue
- Skin changes (sclerodactyly)
- Esophageal dysfunction
- Pulmonary involvement (interstitial lung disease, hypertension)
Diagnosis
- High-titer anti-U1 RNP antibodies
- Clinical features overlapping multiple connective tissue diseases
- Specialized rheumatology evaluation
Treatment
- NSAIDs for joint pain
- Hydroxychloroquine
- Corticosteroids for flares
- Immunosuppressants for serious involvement
- Calcium channel blockers for Raynaud's
- Treatment of specific organ complications
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.
References
- American College of Rheumatology. MCTD Patient Information.