Merkel Cell Carcinoma

Merkel cell carcinoma is a rare and aggressive type of skin cancer that often presents as a rapidly growing, painless, shiny nodule on sun-exposed skin. Early detection is critical.

Quick Facts

  • ICD-10: C44.9
  • Mnemonic: AEIOU clinical features

AEIOU Features

  • Asymptomatic (painless)
  • Expanding rapidly
  • Immune suppression
  • Older than 50
  • UV-exposed fair skin

Treatment

  • Wide local excision
  • Sentinel lymph node biopsy
  • Radiation therapy
  • Immunotherapy (PD-1/PD-L1 inhibitors) — major advance for advanced disease

When to See a Doctor

Any new, rapidly growing skin lesion in older adults or immunocompromised patients should be evaluated promptly.

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.

References

  • American Academy of Dermatology. Merkel Cell Carcinoma.