Squamous Cell Carcinoma

Squamous cell carcinoma (SCC) is the second most common skin cancer. It usually develops in sun-damaged skin and can spread to lymph nodes and other organs if not treated.

Quick Facts

  • ICD-10: C44
  • Spread risk: Higher than BCC
  • Treatable if caught early: Yes

How It Looks

  • A firm red nodule
  • A flat sore with a scaly crust
  • A new sore on an old scar or ulcer
  • A rough, scaly patch on the lip
  • A red sore or rough patch inside the mouth
  • A wart-like growth

SCC commonly appears on the head, neck, hands, and forearms.

Risk Factors

  • Chronic sun exposure
  • Fair skin
  • Older age and male sex
  • History of actinic keratosis
  • Immunosuppression
  • HPV infection (some SCCs)
  • Chronic skin injury or scars

Treatment

  • Surgical excision
  • Mohs surgery for high-risk locations
  • Curettage and electrodessication for low-risk small lesions
  • Radiation therapy
  • Immunotherapy or targeted therapy for advanced disease

When to See a Doctor

See a dermatologist promptly for any new, growing, bleeding, or non-healing skin lesion, especially on sun-exposed areas.

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.

References

  • American Academy of Dermatology. Squamous Cell Carcinoma.