Bullous Pemphigoid

Bullous pemphigoid is an autoimmune blistering skin disease that mostly affects older adults. The body produces antibodies that attack the deeper part of the skin, leading to large, tense, itchy blisters.

Table of Contents

Quick Facts

  • ICD-10: L12.0
  • Common in: Adults over 70

Symptoms

  • Large, tense fluid-filled blisters
  • Severe itching, sometimes weeks before blisters appear
  • Red, raised patches that look like hives
  • Most often on arms, legs, abdomen, groin
  • Mucous membrane involvement is uncommon

Diagnosis

  • Skin biopsy with direct immunofluorescence
  • Blood tests for specific antibodies

Treatment

  • Topical corticosteroids (often high-potency, large body surface)
  • Oral corticosteroids for severe disease
  • Steroid-sparing immunosuppressants
  • Tetracycline antibiotics (anti-inflammatory effect)
  • Rituximab for refractory cases

Related Conditions

Stevens-Johnson Syndrome

Different severe skin disease

 Itching of Skin

Cardinal symptom
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.

References

  • American Academy of Dermatology. Bullous Pemphigoid Resources.