Waldenström Macroglobulinemia

Waldenström macroglobulinemia is a rare slow-growing type of non-Hodgkin lymphoma in which abnormal cells produce excessive amounts of IgM antibody. The condition can cause hyperviscosity, anemia, and neuropathy.

Table of Contents

Quick Facts

  • ICD-10: C88.0
  • Type: Indolent lymphoma

Symptoms

  • Fatigue (often from anemia)
  • Easy bruising or bleeding
  • Enlarged lymph nodes, liver, or spleen
  • Numbness or tingling (neuropathy)
  • Vision changes (hyperviscosity)
  • Headache, dizziness
  • Weight loss, night sweats

Diagnosis

  • Blood tests showing high IgM
  • Bone marrow biopsy
  • MYD88 mutation testing
  • Imaging

Treatment

  • Watch and wait for asymptomatic patients
  • BTK inhibitors (ibrutinib, zanubrutinib)
  • Rituximab-based chemotherapy
  • Plasmapheresis for severe hyperviscosity

Related Conditions

Lymphoma

Broader category

 Lymphadenopathy

Common feature
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.

References

  • International Waldenstrom's Macroglobulinemia Foundation. Patient Resources.