McCune-Albright Syndrome
McCune-Albright syndrome is a rare disorder caused by GNAS gene mutations that occur during fetal development. The classic triad is fibrous dysplasia of bone, café-au-lait skin patches, and endocrine overactivity (especially precocious puberty).
Table of Contents
Features
- Fibrous dysplasia (bone lesions, fractures, deformity)
- Café-au-lait skin patches with irregular borders
- Precocious puberty
- Other endocrine excess (hyperthyroidism, growth hormone excess)
Management
- Bisphosphonates for bone disease
- Surgery for fractures/deformity
- Hormone suppression for precocious puberty
- Multidisciplinary care
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.
References
- NIH. McCune-Albright Resources.