Growth Hormone Deficiency
Growth hormone deficiency (GHD) is reduced production of growth hormone from the pituitary gland. It causes short stature in children and metabolic effects, fatigue, and reduced quality of life in adults. Replacement therapy is effective.
Quick Facts
- ICD-10: E23.0
- Treatment: Daily injectable or weekly GH
Symptoms
Children
- Slow growth and short stature
- Delayed puberty
- Increased belly fat
- Younger-looking face for age
Adults
- Reduced muscle mass and strength
- Increased body fat (especially abdominal)
- Fatigue, low energy
- Mood changes
- Reduced bone density
- Lipid abnormalities
Causes
- Pituitary tumors or surgery
- Radiation to the brain
- Head injury
- Congenital pituitary disorders
- Idiopathic in many childhood cases
Diagnosis
- Growth velocity assessment (children)
- IGF-1 level
- GH stimulation tests (definitive)
- MRI of the pituitary
Treatment
Recombinant human growth hormone, given by subcutaneous injection. Treatment continues until growth is complete (children) or as ongoing therapy for symptomatic adult deficiency.
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. If you are experiencing a medical emergency, call your local emergency number immediately.
References
- Endocrine Society. Growth Hormone Deficiency Guidelines.